Alpha Genome Atlas:
Google has unveiled the AlphaGenome Atlas.
- AlphaGenome Atlas is an extensive, high-resolution digital directory designed to predict how genetic alterations impact molecular biology.
- It is an AI-powered interactive resource, mapping the predicted impact of all 9 billion DNA variants.
- It works in a regular web browser, without any coding required, and is free for academic researchers.
- It is a 1 petabyte (PB) dataset containing every single possible nucleotide variant alongside an AlphaGenome Variant Impact (AVI) score.
- It is available to researchers around the world, with coding and non-coding variations available.
- It provides several powerful, interconnected resources, allowing researchers to link variants directly to the functional DNA sequences they disrupt.
Key Technical Features:
- Molecular effect predictions: Atlas contains thousands of molecular effect predictions for each variant, across multiple important aspects of gene regulation, spanning hundreds of human and mouse cell types and tissues.
- AVI score: A single number describing the impact for each genetic variant.
- AVI feature attributions: Each AVI score is also linked to distinct biological features driving it, such as the aspects of gene regulation predicted by AlphaGenome or the protein impact score from AlphaMissense.
- DNA sequence motifs: A comprehensive collection of over 2,500 recurrent DNA sequences — the “words” of the genome — and their locations.
