Envelope Dimer Epitope:
A new study published in Science Translational Medicine has identified Envelope Dimer Epitope (EDE)-like antibodies as a major driver of cross-serotype immunity against dengue.It is a quaternary epitope found on the envelope (E) protein of the dengue virus surface, formed when two E proteins pair together. Function: A key immune target capable of generating broad, cross-serotype protection. Present only in mature virus particles, making it a precise target for neutralising antibodies.The Envelope Dimer Epitope (EDE) is a unique structure on the outer covering of the dengue virus, formed when two envelope (E) proteins pair up.
