Acute Lymphoblastic Leukaemia: Study
The multi-institutional study of 830 adult ALL patients treated at eight academic centres between found that about one in 10 adults diagnosed with Acute lymphoblastic leukaemia (ALL ) had a mutation in TP53.
- Acute lymphoblastic leukaemia or acute lymphocytic leukaemia is a type of blood cancer that affects the white blood cells and bone marrow.
- It is a fast-growing cancer. It is the most common type of paediatric cancer.
- Bleeding from the gums, Bone pain, Fever, Frequent infections and Frequent or severe nosebleeds etc.
- It occurs when a bone marrow cell develops changes (mutations) in its genetic material or DNA.
- Types of Acute Lymphoblastic Leukaemia: The World Health Organization classifies acute lymphoblastic leukemia into two main groups:
- B-cell lymphoblastic leukemia/lymphoma: Starts in immature cells that ordinarily develop into B-cell lymphocytes. B-cell ALL is the most common subtype.
- T-cell lymphoblastic leukemia: Starts in immature cells that ordinarily develop into T-cell lymphocytes. T-cell ALL is less common.
- Treatment: It may include chemotherapy or targeted drugs that specifically kill cancer cells.
