Nitric Oxide Against Drug-Resistant Pneumonia:
A study has shown that high-dose inhaled nitric oxide (300 ppm) significantly reduced drug-resistant pneumonia, offering a possible new strategy against antimicrobial resistance.Drug-resistant pneumonia, particularly caused by Pseudomonas aeruginosa, is a serious complication in Intensive Care Units (ICUs), responsible for about one in five hospital pneumonias.It is an inflammatory condition of the lung alveoli caused by bacteria that exhibit resistance to one or more antibiotics typically used for treatment.Nitric oxide (NO) is a colorless gas, classified as an oxide of nitrogen. It is a stable free radical with an unpaired electron, making it highly reactive with a short half-life (seconds to minutes). It diffuses readily across cell membranes.In mammals, NO is synthesized from the amino acid L-arginine by a family of enzymes called nitric oxide synthases (NOS).
