TDP1 : Cancer Treatment
Recent research by scientists at the Indian Association for the Cultivation of Science (IACS), Kolkata, has identified a new approach for cancer treatment by targeting a DNA repair enzyme called TDP1.
- Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a DNA repair enzyme that plays a crucial role in fixing DNA damage induced by Topoisomerase 1 (Top1) inhibitors during cell division.
- TDP1 becomes particularly active during the mitotic phase, helping repair drug-induced DNA damage, allowing cancer cells to survive chemotherapy.
- The enzyme’s activity is regulated by Cyclin-dependent kinase 1 (CDK1), which enhances TDP1’s ability to resolve DNA damage through phosphorylation.
