Nano-MIND Technology:
Researchers from the Korean Institute of Basic Science have developed a magnetogenetics technology named Nano Magnetogenetic Interface for NeuroDynamics (Nano-MIND) which has been demonstrated on mice
- Nano-MIND (Magnetogenetic Interface for NeuroDynamics) technology, opens up new possibilities for understanding and manipulating complex brain functions such as cognition, emotion, and motivation.
- It allows for wireless, remote, and precise modulation of specific deep brain neural circuits using magnetism.
- This innovative approach leverages magnetic fields and magnetized nanoparticles to selectively activate targeted brain circuits, offering a significant advancement over existing methods of brain manipulation.
Highlights of the research:
- The research team demonstrated the technology’s capabilities by activating specific neurons in different brain regions of mice.
- One notable achievement was the activation of inhibitory GABA receptors in the medial preoptic area (MPOA), which is responsible for maternal behaviours.
- When these neurons were stimulated in non-maternal female mice, the animals exhibited significantly increased nurturing behaviours, mimicking those of maternal mice.
- The researchers also successfully regulated feeding behaviours by targeting motivation circuits in the lateral hypothalamus.
- Activation of inhibitory neurons in this area resulted in a remarkable 100% increase in appetite and feeding behaviours in mice.
- Conversely, when excitatory neurons were activated, the mice showed a more than 50% reduction in appetite and feeding behaviours.
