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Hydroxyurea : To Treat Sickle Cell Disease

Hydroxyurea : To Treat Sickle Cell Disease


The Indian Council of Medical Research (ICMR) is seeking to develop a pediatric oral formulation of hydroxyurea to treat sickle cell disease in India, where over 20 million individuals are affected.

  • Currently, hydroxyurea is mainly available in 500 mg capsules or 200 mg tablets, making dosing for children challenging.
  • This initiative is crucial, especially with the launch of the National Mission to eliminate Sickle Cell Anemia/SCD by 2047.

SCD (Sickle Cell Disease):

  • Sickle Cell Disease (SCD) is a genetic disorder that affects the shape of red blood cells, causing them to become sickle-shaped instead of round.
  • This abnormal shape can lead to various complications, including pain, anemia, and organ damage.
  • SCD is one of the most common inherited blood disorders and can result in serious health issues, including stroke and organ failure.