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Nobel Prize In Medicine 2023

Nobel Prize In Medicine 2023:

The Nobel Prize in Physiology or Medicine for 2023 has been awarded to Katalin Kariko and Drew Weissman for their groundbreaking research on nucleoside base modifications that played a pivotal role in the development of highly effective mRNA vaccines against COVID-19.

  • Kariko and Weissman identified a key problem: dendritic cells in the body perceived lab-grown genetically engineered mRNA as foreign, triggering an inflammatory response.
  • The Breakthrough:
    • To address this issue, they experimented with chemically modifying the bases in mRNA.
    • By introducing unique chemical alterations in the mRNA bases and delivering them to dendritic cells, they reduced the inflammatory response.
    • These groundbreaking results were published in 2005, with further developments in 2008 and 2010.