Nobel Prize In Medicine 2023:
The Nobel Prize in Physiology or Medicine for 2023 has been awarded to Katalin Kariko and Drew Weissman for their groundbreaking research on nucleoside base modifications that played a pivotal role in the development of highly effective mRNA vaccines against COVID-19.
- Kariko and Weissman identified a key problem: dendritic cells in the body perceived lab-grown genetically engineered mRNA as foreign, triggering an inflammatory response.
- The Breakthrough:
- To address this issue, they experimented with chemically modifying the bases in mRNA.
- By introducing unique chemical alterations in the mRNA bases and delivering them to dendritic cells, they reduced the inflammatory response.
- These groundbreaking results were published in 2005, with further developments in 2008 and 2010.