Zebrafish : Ability To Regenerate Aged Discs In Human Vertebrae
Scientists discovered that a protein found in Zebrafish can regenerate aged discs in human vertebrae.
- A study by Agharkar Research Institute (ARI), Pune, an autonomous institute of the Department of Science and Technology, discovered that a protein called Cellular communication network factor 2a (Ccn2a) secreted from intervertebral disc cells induces disc regeneration in aged degenerated discs in humans.
- It is done by promoting cell proliferation and cell survival by modulating the pathway called the FGFR1-SHH (Fibroblast growth factor receptor-Sonic Hedgehog) pathway.
- Zebrafish is a small (2-3 cm long) freshwater fish found in tropical and subtropical regions.
- The fish is native to South Asia’s Indo-Gangetic plains, where they are mostly found in the paddy fields and even in stagnant water and streams.
- It attracts developmental biologists due to its adequate regeneration capacity of almost all its organs, including the brain, heart, eye, and spinal cord.
- It has a similar genetic structure (around 70%) to humans.
- IUCN Red List Status: Least concerned.