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REGEN-COV2 – Monoclonal Antibodies on Covid 19

Monoclonal antibodies:

An experimental monoclonal antibody cocktail, REGEN-COV2, has been found to be a life-saving treatment for some of the most severely affected Covid-19 patients, results of a clinical trial in the UK have shown.

  • However, Such therapies are expensive because they are difficult to make and take a lot of time.
  • They are artificially created antibodies that aim to aid the body’s natural immune system.
  • They target a specific antigen — a protein from the pathogen that induces immune response.
  • Monoclonal antibodies can be created in the lab by exposing white blood cells to a particular antigen.
  • To increase the quantity of antibodies produced, a single white blood cell is cloned, which in turn is used to create identical copies of the antibodies.
  • In the case of Covid-19, scientists usually work with the spike protein of the SARS-CoV-2 virus, which facilitates the entry of the virus into the host cell.
  • In a healthy body, the immune system is able to create antibodies — tiny Y-shaped proteins in our blood that recognise microbial enemies and bind to them, signalling the immune system to then launch an attack on the pathogen.
  • However, for people whose immune systems are unable to make sufficient amounts of these antibodies, scientists provide a helping hand- using monoclonal antibodies.

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